There have been significant concerns around the ingredient,1,3-Dimethylamylamine. On April 27, 2012, the FDA issued a warning letter to all manufactures of supplements containing 1,3-Dimethylamylamine for marketing a product “for which evidence of the safety of the product had not been submitted to the FDA”. In the FDA’s press release, they stated that
DMAA is known to narrow the blood vessels and arteries, which can elevate blood pressure and may lead to [heart problems]. The agency has received 42 adverse event reports on products containing DMAA. While the complaints do not establish that DMAA was the cause of the incidents, some of the reports have included cardiac disorders, nervous system disorders, psychiatric disorders, and death.
Given that products using DMAA tend to combine them with ingredients that can increase its effect, the safety concerns are warranted.
Bottom Line: There are a number of safety questions surrounding DMAA, so one should be careful.
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